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GLP-1s appear to improve insulin signaling across the hypothalamic-pituitary-gonadal axis, which could explain these benefits

Introduction The development of new compounds in recent decades has substantially improved the pharmacotherapy of type 2 diabetes (T2D) by improving achievement of metabolic targets while mitigating specific side effects (e.g., weight gain, hypoglycemia) frequently observed in patients treated with traditional hypoglycemic drugs such as insulin and sulfonylureas

Average weight loss is 13.6% with the daily Wegovy pill vs

Nausea (43%), diarrhea (33%), and vomiting (21%) are the most common, consistent with other GLP-1 medications

The fatigue typically peaks 4 to 8 hours after injection and can linger for 24 to 48 hours

Health regulators have approved two new GLP1 pills one from the makers of Ozempic and Wegovy and another from the makers of Mounjaro and Zepbound