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Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

This regulated necrotic cell death is activated in response to Fas/FasL signaling, CD59 ligation combined with pore formation, mediated by ROS, ceramide, and advanced glycation end products (AGEs) [28]

doi: 10.1189/jlb.0404216 33 CrossARJonesOT

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These ROS are primarily derived from the mitochondrial Electron Transport Chain (ETC), enzymes like xanthine oxidase, NADPH oxidase, and cytochrome P450, as well as transition metals like iron and copper