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Tirzepatide (Mounjaro, Zepbound) is a dual GIP and GLP-1 receptor agonist used for type 2 diabetes and weight management

The effectiveness of once-daily subcutaneous liraglutide administration for weight loss management in adults was established in five large-scale randomized multicentre phase 3 trials [49,50,51,52,53], four of which were part of the SCALE program (Satiety and Clinical AdiposityLiraglutide Evidence in nondiabetic and diabetic individuals), leading to its approval at a dose of 3.0 mg subcutaneous once-daily (weekly increased from 0.6 mg to 3 mg/day)

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Its ubiquitination and degradation can limit the activation of antioxidant genes, thereby reducing the survival and proliferation of cancer cells

In addition, it increases the secretion of insulin by the pancreas and plays a pivotal role in glycemic control and lipid metabolism [4]

There is no authorised UK reconstitution ratio for retatrutide