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Among the tissues and organs crucial in regulating glucose and lipid metabolism, pancreas, brain, and adipocytes express GIP receptors (GIPRs), while pancreas, brain, and gastrointestinal tract are rich in GLP-1 receptors (GLP-1Rs) (40)

10.1158/0008-5472.CAN-20-0600 255 ZhaoY.WangL.PanJ

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Four overlayed models generated by PHENIX ensemble refinement are shown in each panel to demonstrate the confidence that can be assigned to interactions with the receptor described in this study