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Fig.3 Proportion of patients achieving MASH resolution without worsening of fibrosis with tirzepatide [6] While GLP-1 RAs are proving effective in treating MASH, their lack of direct action on liver tissue could limit their effectiveness in patients with advanced liver fibrosis or cirrhosis

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The data used in this publication was provided by the Conticanet (Connective Tissue Cancer Network) database ( and the French sarcoma network RRePS ( These databases are financially supported by Conticanet and INCa (Institut National du Cancer)