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We thank the Humanized Mouse Platform: Patient Derived Tumor, Gut Microbiota Transplantation and Gene Modification Service at the National Core Facility for Biopharmaceuticals, National Laboratory Animal Center, Taiwan for providing the germ-free mouse facilities

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Another methodological consideration is the use of a computerized analysis for FST that was developed in our laboratory to continuously follow the limbs of rats 35 and detect fine alterations in mobility throughout the test