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Upon placement of the compound into the cryo-EM map and structural refinement we find that 9 adopts two conformations in both subunits, spanning the three subpockets A, B and C (Fig

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Construction of the inducible reporter strains The plasmid pALC2084, which contains a tetracycline (Tet)-inducible GFP-expressing cassette 67 (kindly provided by Ambrose Cheung, Dartmouth College, Hanover), was first transformed into S

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10.1007/s12035-014-8995-z Mol