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In recent years, accumulating evidence suggests that oxidative stress, mitochondrial dysfunction, and disturbances in iron homeostasis serve as upstream triggers driving these pathological cascades (Luo et al., 2019

doi: 10.1007/s12199-007-0019-4 [DOI] [PMC free article] [PubMed] [Google Scholar] 132

When administered either orally, intraperitoneally, or intracerebroventricularly at various doses, Dihexa-treated rats showed significantly improved performance in both acquisition trials and probe trials measuring spatial memory retention

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