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In these situations both bright light in the early morning and evening melatonin 5 hours before endogenous melatonin onset secretion (0.5-5 mg) has been shown to advance sleep time significantly (102), the magnitude of the advanced shift being dose-dependent

GLP-1s are proven to decrease cardiovascular events, sleep apnea, and even kidney disease

GLP-1 receptor agonists have been approved to treat diabetes since 2005 and obesity since 2014

Tirzepatide advances this mechanism by functioning as a dual agonist (activaor)