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doi: 10.1007/s00125-008-1053-5 160 ChristensenMMHHjlundKHother-NielsenOStageTBDamkierPBeck-NielsenHet al

PMID: 18334612

The clinical investigators specifically noted that "gastrointestinal adverse events were partially mitigated by the use of a lower starting dose." Starting at 1 mg, which is what the Phase 3 TRIUMPH trials use, provides even more tolerability protection

From the GLP Collection range, handled with the same preparation steps as this one

This balancing act is critical because glucagon classically raises blood glucose (opposing insulin's effects), but when combined with GLP-1 agonism, the glucose-raising effects are counteracted while the metabolic benefits of increased energy expenditure and hepatic fat burning are preserved

Donnelly D (2012) The structure and function of the glucagon-like peptide-1 receptor and its ligands