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According to FDA prescribing information, nausea occurs in approximately 15-44% of patients depending on the specific agent and dose, with vomiting, diarrhea, constipation, and abdominal pain also frequently reported

using a lower dose (300 mg/day) demonstrated significant symptomatic improvements in PD patients with wearing-off

Supply and counterfeit risks Both agents have faced global shortages or stock issues and emerging counterfeit supply chains

10.1002/adtp.202400136