Metformin suppresses cancer initiation and progression in genetic mouse models of pancreatic cancer
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[DOI] [PubMed] [Google Scholar] Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, DuGar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL
January 2024: CBS News coverage indicated that the FDAs quarterly FAERS potential-safety-signals report (January-March 2024) included GLP-1 receptor agonists for a potential signal involving dysaesthesia
However, the physiological half-life of GLP-1 in circulation is very short (less than 2 min), which can be attributed to both rapid proteolytic cleavage of the amide bond of alanine at position 8 (Ala8) in the N-terminus by ubiquitous dipeptidyl peptidase IV (DPP-IV), which results in the removal of the two N-terminal amino acids leading to the formation of a truncated inactive form 10,11 and clearance by the kidney as well
