Its the first thought that usually affects peoples preferences in these medications
For people with type 2 diabetes receiving concomitant insulin or sulfonylureas, there is a theoretical risk of hypoglycaemia based on class experience with GLP-1-based therapies
One note specific to Zepbound and Mounjaro: a direct provider consultation may be required before prescribing - not just an intake review
A spokesperson for the regulator said scam websites should be reported to Scamwatch for assessment to determine whether they should be taken down
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
This discrepancy between results in animal models and clinical studies may partly be due to myocardial insulin resistance in severely failing hearts and the use of beta-blockers [21]