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Clinical trials consistently show that patients who escalate doses more slowly report milder and shorter-duration side effects

Since cysteine is known to be neurotoxic in excessive amounts [32], treatment with N-acetylcysteine should not be recommended for patients with glutathione synthetase deficiency as this may increase the intracellular cysteine levels even more

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Monitoring is important during treatment

doi: 10.1016/s0140-6736(14)61335-0 22 SchlosserR

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