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The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity

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And peptides like BPC-157 may result in the growth of more blood vessels, which could be a red flag

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The Kraus 2014 Nature Paper: Why Adipose Research Specifically The 2014 Nature paper by Kraus and colleagues (titled "Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity") established the adipose-NNMT connection that anchors all subsequent NNMT-inhibition research in fat biology