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While bariatric surgery achieved more substantial weight loss, GLP-1 RA therapy was associated with more favorable overall clinical outcomes in patients with idiopathic intracranial hypertension

That translates to roughly 71 pounds off a 249-pound starting weight

Of note, the prevalence of HF varied across these trials from 9% to 24%, and HF events were considered a secondary endpoint

A Network Meta-Analysis Comparing Tirzepatide and Semaglutide. February 11, 2026

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[1] [4] Patients with diabetes require monitoring for diabetic retinopathy, particularly if they have a history of retinopathy and rapid improvement in glycaemic control