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Its well-known adverse events, e.g., interstitial pulmonary fibrosis, seizures, liver veno-occlusive disease, or sinusoidal obstruction syndrome [96] seem to be caused by glutathionyl-tetrahydrothiophene, a metabolite that derives from the irreversible GSH conjugation [97,98]

ZakkarMVan der HeidenKLuongLAChaudhuryHCuhlmannSHamdulaySSet alActivation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state

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Building glutathione levels with cysteine supports liver detoxification function

doi:10.1016/B978-1-4557-0891-8.00032-4

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