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Octane, in contrast, remains in the liquid phase all the way up to 128 o C, due to the increased influence of attractive London forces, made possible by the larger surface area of the individual molecules

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Note that this nomogram crossing is not unique to the sustained-release products and occurs in up to 10% of patients with acute ingestions of immediate-release APAP * and those with ingestions of APAP with diphenhydramine or opioids *

8 , e2986 (2017)

This is still being studied, but the clinical experience to date is consistent with this hypothesis