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2012), led us to propose that hepsin could significantly diminish the severity of APAP-induced hepatotoxicity by regulating the abundance of hepatic GJ proteins, which may alter the distribution of free radicals between neighboring hepatocytes, thereby potentially increasing oxidative stress

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3), which is known to upregulate the expression of genes involved in amino acid transport or synthesis, one-carbon metabolism, and glutathione biosynthesis 33,34 (Fig

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9 , e2204849 (2022)

10.1074/jbc.M412898200 J