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Creatine draws water into muscle cells, creating a more anabolic cellular environment

Once again, plenty of protein is a must to avoid muscle loss

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Recently, we found that triagonist-induced enhancement of insulin secretion exceeds levels observed with the loose co-administration of the three individual agonists in murine islets [9]

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Critically, the glucagon component in cotadutide does not show this catabolic effect, given that the balance of GCGR and GLP-1R activity within cotadutide has been optimized to achieve the specific benefits of glucagon-induced inhibition of hepatic lipogenesis, while still allowing for metabolic switching in response to glycemic status 13