The clinical evidence base for these agents, both individually and in combination, is still emerging
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Gag is known to interact with the PM via binding to the charged phosphoinositide lipids PIP2 (Ono et al., 2004), which may couple with sphingolipid-rich outer leaflet (Lorent et al., 2020) to produce a transbilayer ordered domain
As the K4 and SPH domains belong to the and subunits of HGF, respectively, such strong K4/SPH interaction would be important for the structural integrity of HGF / heterodimer in addition to the disulfide bond between these two subunits
Moreover, patient adherence is a critical determinant of success, requiring sustained motivation, family support, and multidisciplinary guidance
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