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When food intake drops, water intake often drops with it, because a significant portion of daily hydration comes from food

By month six, regain typically reaches 40-50%, and by twelve months, many return to near-baseline weight unless significant lifestyle modifications remain in place

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(2025) address the growing use of GLP-1 analogs, including tirzepatide, as agents for weight control and body aesthetics, highlighting the potential benefits and risks of unsupervised use

Both are characterized by an excess buildup of fat in the liver, which can lead to damaging inflammation and eventual permanent scarring, or cirrhosis