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ICP was significantly lower in the exenatide group compared to placebo after 12 weeks (exenatide 21.4 (4.0) cmCSF, placebo 26.0 (4.4) cmCSF p = 0.058)

For manufacturers, this presents a dilemma

J Clin Endocrinol Metab 86 : 58135818 Zick Y (2004) Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

There is potential for future MRS studies using 7 Tesla scanners to provide more detailed analyses of target brain regions by using ROIs with a smaller volume

doi: 10.1016/j.micinf.2004.10.012 100 FonsecaCTPacificoLGBarsanteMMRassiTCassaliGDOliveiraSC

Herrett E, Gallagher AM, Bhaskaran K et al (2015) Data resource profile: Clinical Practice Research Datalink (CPRD)