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Because it does not cause water retention, does not cause virilization (masculine characteristics), and avoids cortisol spikes, it is incredibly well-tolerated by women

In a randomized controlled trial, the topical steroid combination (betamethasone) with a narrow-band UVB (NB-UVB) and topical calcipotriol therapy substantially improved repigmentation at six months compared to NB-UVB alone and NB-UVB with topical calcipotriol 25

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(2025, February 15)

Other Serious Side Effects Can Include: Pancreatitis (inflamed pancreas) Cholelithiasis (gallbladder disease) Kidney damage Low blood sugar (hypoglycemia) Allergic reactions (including swelling of the face, tongue, or throat

Some may experience mild side effects like nausea, stomach discomfort, or heartburn