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An increase in respiratory drive elicited by GSGee may decrease the number of sighs and decrease the number of apneas, but that would not be defined definitively by a change in the rejection index since this index also includes sniffs and changes in respiratory waveforms due to behavioral movements 87 , although it must be noted that the fentanyl-treated rats (those that received vehicle or GSHee) were basically immobile throughout the ventilatory study

Meier C, Hardtstock P, Joost S, Alla V, Ptzer BM

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We have previously demonstrated a homeostatic imbalance of purine catabolism ( Firstly, several purine metabolites (UA, Gr, or Xan) are each significantly correlated with TRP in all subjects