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de Zeeuw D, Akizawa T, Audhya P, Bakris GL, Chin M, Christ-Schmidt H, et al

In studies with rodents, tirzepatide caused thyroid tumors, including thyroid cancer

Gastrointestinal side effects are the most frequently reported adverse reactions with GLP-1 receptor agonists, particularly during the initial weeks of treatment or following dose escalation

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If constipation is intolerable on one medication, switching to the other may help, but it is not guaranteed

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