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Drug dosing isnt guesswork pharmaceutical companies spend years testing for the safest and most effective dose

Cheetham TC, Marcy SM, Tseng HF, et al

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Wegovy has a half-life of seven days, according to the drugs prescribing information, meaning that 50% of the original concentration will have been removed from the body one week after stopping it

This is illustrated by the mathematical considerations of Henderson & Riley (1945) in their classical paper on extrapolating data from a small test population to large numbers of users