Why GLP-1 is the Target of Modern Weight Loss Medications The global obesity epidemic has driven intense research into therapeutic strategies for weight loss
While more research is needed, the safety profile of GLP-1 agonists in treating diabetes and obesity offers hope for their future use in addiction therapy
However, current evidence points to at least partial mediation through central mechanisms as direct activation of central GIPRs can suppress food intake and decrease body weight, whereas deletion of these receptors blunts such effects and protects against obesity by altering feeding behavior (NamKoong et al., 2017
The odds of them sustaining this weight loss is tremendously greater than with GLP-1s
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
thyroid cancer or hyperthyroidism, gastroparesis, pancreatic cancer or pancreatitis, MEN2 syndrome, or inflammatory bowel disease)