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The effect of the endocannabinoid system including anandamide: In the CNS, CB1 receptors are expressed pre-synaptically on both glutamatergic and GABAergic interneurons, and activation of these receptors results in inhibition of synaptic transmission, including glutamate release It slows down the activity which leads to seizures

doi:10.1016/j.jsbmb.2006.12.102

Advanced molecular analysis using nuclear magnetic resonance spectroscopy, viscosimetry studies, and molecular dynamics simulations has revealed that Pinealon can penetrate into the major groove of the DNA double helix, where it forms specific molecular contacts with nucleotide bases

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Zh ., 1991, 63(5), 112-116