While theres not much research out there, one review found that those taking 1.7 mg semaglutide lost roughly 5% less weight than their counterparts taking 2.4 mg
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Weight gain was associated with increased osteoporosis risk among those not on a GLP-1, while weight gain was not associated with statistically significant change in osteoporosis risk for those on a GLP-1
In type 2 diabetes, postprandial GLP-1 secretion may be reduced , leading to an impaired insulin response