For renal impairment, although most GLP-1 agents have minimal renal clearance, impaired kidney function increases the risk of adverse events such as dehydration from vomiting or decreased drug clearance in polypharmacy
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Intarcia , a US biotech, had to terminate two Phase III trials in January after the FDA rejected its drug-delivery device for type 2 diabetes
Or remember that 0.10 mL = 10 units, 0.25 mL = 25 units, 0.50 mL = 50 units, and 1.00 mL = 100 units
-cell incretin sensitivity expressed as area under the curve of the insulin secretion rate during the first 30 min of the OGTT plotted against the area under the curve of GLP-1 secretion during the first 30 min of the OGTT 83