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That is, investigations are warranted to better understand the potential benefit of combined use of GLP-1 RAs and SGLT2 inhibitors in HF with specific focus on the sequence of treatment initiation and the suitable population, including by HF phenotype and presence of diabetes
( 10.1016/j.ejphar.2017.10.049) [DOI] [PubMed] [Google Scholar] 45.Muskiet MHA, Tonneijck L, Smits MM, Van Baar MJB, Kramer MHH, Hoorn EJ, Joles JA, Van Raalte DH
They are clinical observations being documented and shared among practitioners
Compounded GLP-1 medications are not FDA-approved finished products
Why? Fasting is a common strategy during GLP-1 therapy, but hunger during fasting periods can derail progress
Important safety considerations include a boxed warning for medullary thyroid carcinoma (MTC) risk with most GLP-1 medications, which are contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)
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