starting tirzepatide after semaglutide Switching from to Tirzepatide: What to Expect — Affinity Whole Health Switching from Semaglutide to Tirzepatide:

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Patients should contact their healthcare provider if they experience any of the following: Severe or worsening fatigue that interferes with daily activities, work, or self-care, or fatigue that progressively worsens despite implementing management strategies

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For more information about possible side effects, see these Contrave side effects and Wegovy side effects articles

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Mutations of any of these residues reduces GPX4 activity