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The research was supported in part by the National Institute of Dental and Craniofacial Research (R01DE025037 and R01DE027374).

The responsible path for athletes and their practitioners is to monitor the clinical-trial landscape while focusing on approaches with established safety profilesPRP, evidence-based rehabilitation, and collagen peptide supplementation

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Furthermore, CH-NPs release the drug into the cytoplasm by dissolving the assembly at the endo-lysosomes acidic pH with ligands specific to the tumor via pH-cleavable bonds (Xu et al., 2013)