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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

While they are not yet available for use, research is underway that could eventually bring these therapies into mainstream care

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It helps to penetrate deep inside the skin cells and causes the transformation within a few days