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Mattes WB, Daniels KK, Summan M, Xu ZA, Mendrick DL

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To evaluate the effect of Melatonin administration on mechanical and thermal pain sensitivity in RIFM, the study employed a series of behavioral assessments, such as the von Frey filament test, cold allodynia test, hot plate test, Randall-Sellito test, and tail suspension test, to comprehensively characterize pain responses associated with FM

Furthermore, VEGF may also increase the permeability of blood vessels, which might enable the extravasation of plasma proteins and contribute to the formation of a primitive vascular scaffold, thereby potentially promoting the process of angiogenesis