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Retatrutide is a triple-hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors, while Zepbound (Tirzepatide) is a dual-agonist working on GLP-1 and GIP

So vi phu thut, GLP-1RA c mc an ton cao hn, vi cc tc dng ph ch yu l ri lon tiu ha nh, trong khi phu thut gim cn i km vi cc ri ro lin quan n can thip phu thut v thi gian hi phc ko di

There is no FDA-approved patch for a GLP-1, says Natasha Bhuyan, MD, a board-certified family physician at Amazon One Medical in Phoenix

Retatrutide leverages this same dual pathway while adding something tirzepatide cannot

Reviewed February 2026

This single difference in receptor targeting is the primary reason Retatrutide exhibits higher energy expenditure and fat-burning capabilities