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Agbai, MD, a dermatologist at UC Davis Health in Sacramento, California, who specializes in multicultural dermatology

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In contrast, FGF23 binds to the KlothoFGFR complex and activates the Mitogen-Activated Protein Kinase/Extracellular signal-Regulated Kinase 1 and 2 pathway, leading to the suppression of CYP27B1 and upregulation of the catabolic enzyme 24-hydroxylase (CYP24A1), which accelerates the degradation of 1,25(OH)D (13)

For example, a selective pro-apoptotic Bcl-2 inhibitor Venetoclax has been approved for the treatment of chronic lymphocytic and acute myeloid leukemia [74]