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If the evidence base changes what "well-formulated" means, we'll follow the evidence and we'll tell you if we do

Deficient or even insufficient levels of vital nutrients would increase the severity and frequency of migraine attacks

They are expressed in the Central Nervous System (CNS) and various peripheral tissues and give rise to several active peptides including -endorphin, met- and leu-enkephalin, dynorphin and neodynorphine respectively

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The mechanistic evidence sits with the individual peptides, strongest for GHK-Cu