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The peptide preserves mitochondrial integrity by protecting against superoxide radical accumulation in mitochondrial compartments, maintaining efficient energy production and preventing mitochondrial-derived oxidative stress

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The piezoelectric, non-selective cation channels (Piezo), non-selective cation channels of the transient receptor potential (TRP) family, and Ca 2+ -activated chloride channels of the transmembrane protein 16/Anoctamin family (TMEM16/Ano) play an essential role in Ca 2+ -dependent cell death, including apoptosis and ferroptosis, under mechanical stimulation (Kunzelmann et al., 2019

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